Steroids, specifically glucocorticoids, have various roles in fertility treatment, particularly in the context of assisted reproductive technologies (ART) and certain reproductive disorders. Glucocorticoids are synthetic versions of natural hormones produced by the adrenal glands, such as cortisol.
Steroids & Fertility
Uses of steroids in fertility treatment
Immune-related Fertility Issues: In some cases, fertility issues may be related to immune system dysfunction, such as an overactive immune response that affects implantation and pregnancy success. Glucocorticoids can help suppress the immune response, making the uterine environment more receptive to embryo implantation.
Recurrent Pregnancy Loss (RPL): Women experiencing recurrent pregnancy loss may benefit from steroid treatment. The rationale is that steroids can help reduce inflammation in the uterus, which could be contributing to the repeated miscarriages.
In Vitro Fertilization (IVF): Glucocorticoids have been used in IVF cycles to improve implantation rates and increase the chances of successful pregnancy outcomes. They may help reduce inflammation and immune responses that could interfere with embryo implantation.
Polycystic Ovary Syndrome (PCOS): In some cases of PCOS, women may have elevated androgen levels, which can affect fertility. Steroids may be prescribed to help suppress androgen production and improve hormonal balance.
Anti-inflammatory Effects: Steroids have potent anti-inflammatory properties, and they may be used to address inflammation-related fertility issues or conditions affecting the reproductive organs.
In summary
Steroids are not routinely used as a first-line treatment for infertility, and their use should be part of a comprehensive fertility treatment plan tailored to each individual’s needs.