You may be referred for IVF with PGT by your fertility specialist or clinical geneticist.
There are different types of PGT:
PGT-M (Monogenic Disorders)
Used when one or both intended genetic parents are carriers or affected by a known genetic condition associated with a single gene mutation (e.g Cystic Fibrosis or Huntington’s Disease). The Reproductive Technology Council (RTC) maintains an Approved Conditions List for PGT-M. If your condition isn’t listed, Oasis will assist with the RTC application process.
PGT-SR (Structural Rearrangements)
Recommended for patients with an abnormal karyotype involving chromosome structure changes. Translocations or rearrangements causing recurrent pregnancy loss or developmental defects are automatically approved. For duplications, microdeletions, insertions, or inversions with uncertain significance, an RTC application is required and we’ll guide you through this.
PGT-A (Aneuploidy Screening)
PGT-A is used to check for aneuploidy which is an abnormal number of chromosomes in an embryo. This can lead to implantation failure, miscarriage, or certain genetic conditions. Your fertility specialist may recommend PGT-A if you:
- Are already undergoing PGT-M.
- Are over 35 years of age.
- Have experienced two or more miscarriages.
- Have had three or more unsuccessful IVF cycles (fresh or frozen transfers).
- Have a family history of aneuploidy and been referred by a geneticist.
If these criteria aren’t met, Oasis will prepare and submit the necessary RTC application, including supporting letters from genetic specialists.